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Ramadan diurnal intermittent fasting modulates SOD2, TFAM, Nrf2, and sirtuins (SIRT1, SIRT3) gene expressions in subjects with overweight and obesity
Department of Medical Laboratory Sciences, College of Health Sciences/Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates.
Department of Basic Sciences, College of Medicine/Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, United Arab Emirates; Medical Biochemistry Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.ORCID iD: 0000-0001-5394-9082
Rehabilitation Services, Periphery Hospitals, Ministry of Health, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.
Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
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2019 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 155, article id 107801Article in journal (Refereed) Published
Abstract [en]

Aim: A growing body of evidence supports the impact of intermittent fasting on normalizing body metabolism and lowering oxidative stress and inflammation. Mounting evidence confirms that oxidative stress and chronic inflammation trigger the way for the development of metabolic diseases, such as diabetes. This research was conducted to evaluate the impact of Ramadan intermittent fasting (RIF) on the expression of cellular metabolism (SIRT1 and SIRT3) and antioxidant genes (TFAM, SOD2, and Nrf2).

Methods: Fifty-six (34 males and 22 females) overweight and obese subjects and six healthy body weight controls were recruited and monitored before and after Ramadan.

Results: Results showed that the relative gene expressions in obese subjects in comparison to counterpart expressions of controls for the antioxidant genes (TFAM, SOD2, and Nrf2) were significantly increased at the end of Ramadan, with percent increments of 90.5%, 54.1% and 411.5% for the three genes, respectively. However, the metabolism-controlling gene (SIRT3) showed a highly significant (P < 0.001) downregulation accompanied with a trend for reduction in SIRT1 gene at the end of Ramadan month, with percent decrements of 61.8% and 10.4%, respectively. Binary regression analysis revealed significant positive correlation (P < 0.05) between high energy intake (>2000 Kcal/day vs. <2000 Kcal/day) and expressions of SOD2 and TFAM (r = 0.84 and r = 0.9, respectively).

Conclusion: Results suggest that RIF ameliorates the genetic expression of antioxidant and anti-inflammatory, and metabolic regulatory genes. Thus, RIF presumably may entail a protective impact against oxidative stress and its adverse metabolic-related derangements in non-diabetic obese patients.

Place, publisher, year, edition, pages
Shannon, Ireland: Elsevier Ireland Ltd. , 2019. Vol. 155, article id 107801
Keywords [en]
Gene expression; Intermittent fasting; Nrf2; Ramadan; SIRT1; SIRT3; SOD2; TFAM
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-183654DOI: 10.1016/j.diabres.2019.107801ISI: 000487832100018PubMedID: 31356832Scopus ID: 2-s2.0-85070395875OAI: oai:DiVA.org:liu-183654DiVA, id: diva2:1645046
Note

Funding: This work received a grant from the University of Sharjah (VCRG/R1061/2016).

Available from: 2022-03-16 Created: 2022-03-16 Last updated: 2022-03-25Bibliographically approved

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El-Serafi, Ahmed Taher

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