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Interplay between Epigenetics, Expression of Estrogen Receptor- α, HER2/ERBB2 and Sensitivity of Triple Negative Breast Cancer Cells to Hormonal Therapy
Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE; College of Medicine, University of Sharjah, Sharjah 27272, UAE.
Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE.
Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE.
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2018 (English)In: Cancers, E-ISSN 2072-6694, Vol. 11, no 1, p. 13-13Article in journal (Refereed) Published
Abstract [en]

Triple negative breast cancer (TNBC) cells are resistant to hormonal/targeted therapies. This study aims to investigate epigenetic differences between TNBC and other types of breast cancer and the effect of epigenetic modulation on the response of TNBC cells to hormonal therapy. Thus, we investigated (i) the expression of different epigenetic markers, (ii) the effect of epigenetic modifying agents on the expression of ERα and HER2/ERBB2 and (iii) the effect on the response to tamoxifen in four breast cancer cell lines with different hormonal receptor status. Our results revealed a differential expression patterns of epigenetic markers in the four breast cancer cells. In TNBC cells, histone deacetylases (HDAC) 1 and 2 were less expressed, whereas HDACs 4 and 6 were overexpressed. Interestingly, treatment with epigenetic modifiers resulted in (i) a pronounced increase in the expression of ERα and HER2/ERBB2 along with (ii) an increase in the sensitivity of TNBC cells to tamoxifen. Collectively, this study indicates a different epigenetic background for TNBC cells, which represses the expression of ERα and HER2/ERBB2. Furthermore, we provide here the rationale for the use of epigenetic modifiers to enhance the response of TNBC to hormonal therapy through upregulation of ERα.

Place, publisher, year, edition, pages
MDPI, 2018. Vol. 11, no 1, p. 13-13
Keywords [en]
triple negative breast cancer; estrogen receptor alpha; human epidermal growth factor receptor-2; epigenetics; suberoylanilide hydroxamic acid; 2′-deoxy-5-azacytidine; tamoxifen
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Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-184212DOI: 10.3390/cancers11010013OAI: oai:DiVA.org:liu-184212DiVA, id: diva2:1650588
Available from: 2022-04-07 Created: 2022-04-07 Last updated: 2022-04-28

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Elserafy, Ahmed Taher

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Elserafy, Ahmed TaherMansour, Wael
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