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Statin-induced myopathy SLCO1B1 521T > C is associated with prediabetes, high body mass index and normal lipid profile in Emirati population
College of Medicine and Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, United Arab Emirates; College of Medicine, Cairo University, Egypt.
College of Medicine and Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, United Arab Emirates.
College of Medicine and Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, United Arab Emirates; College of Medicine, Suez Canal University, Egypt.ORCID iD: 0000-0001-5394-9082
College of Medicine and Research Institute for Medical and Health Sciences (RIMHS), University of Sharjah, United Arab Emirates.ORCID iD: 0000-0001-5394-9082
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2018 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 139, p. 272-277Article in journal (Refereed) Published
Abstract [en]

Background: Statin-induced myopathy has been linked to the C allele of a single nucleotide polymorphism (SNP) (rs4149056) of SLCO1B1 gene. This effect is more significant, but not restricted to simvastatin. Many studies have included European, American, African and Southeast Asian ancestries, but few were carried out on Middle Eastern population.

Aim: To detect the prevalence of SLCO1B1 rs4149056 (521T > C) in Emirati population.

Method: We recruited 282 Emiratis through the UAE National Diabetes and Lifestyle Project. Ethical approval was obtained before the study starts. Besides basic data collection, venous blood samples were collected. Fasting blood glucose, Lipid profile, and insulin levels were measured. Genotyping for rs4149056 (521T > C) was tested in triplicates through Real Time-PCR using TaqMan® Drug Metabolism Genotyping Assay. rs2306283 (388A > G) was analyzed for comparison. In addition, presence of minor alleles of both SNPs define stronger association with statin-induced myopathy.

Results: The study included 282 individuals, 52.8% were males with median age of 39.5 years. 10% had Diabetes Mellitus and 23% were hypertensive. Median of body mass index (BMI) was 27.68 kg/m2 in males and 28.38 kg/m2 in females. One-hundred ninety-seven (69.9%) showed abnormal lipid profile (either increased LDL-cholesterol or triglycerides or both). For rs4149056, C allele was present in 21.3% (2.8% homozygous C and 18.4% heterozygous CT). Although homozygous C genotype prevalence was low, compared with Caucasians (4%) and Africans (0%), C allele was associated with a trend of having higher BMI and abnormal lipid profile. C allele subjects were all pre-diabetics with mean glycated hemoglobin above 6%. Mean BMI in CC, CT, and TT genotypes was 30.91 ± 4.4, 29.48 ± 4.2, 27.96 ± 5.5 kg/m2 respectively, with lack of such a trend observed with the different genotypes of the rs2306283 (used for comparison). Abnormal lipid profile was observed in 7/8(87.5%), 38/52(73.1%) and 152/222(70%) of the CC, CT, and TT genotypes respectively.

Conclusion: There is lower prevalence of statin-induced myopathy-linked C allele of rs4149056 in SLCO1B1 gene in Emirati population, compared to Caucasians and Africans. However, there is a trend of higher glycosylated hemoglobin and BMI associated with normal lipid profile in patients having this allele.

Place, publisher, year, edition, pages
Shannon, Ireland: Elsevier, 2018. Vol. 139, p. 272-277
National Category
Cardiac and Cardiovascular Systems Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-184288DOI: 10.1016/j.diabres.2018.03.014ISI: 000432863800030PubMedID: 29534995Scopus ID: 2-s2.0-85044468599OAI: oai:DiVA.org:liu-184288DiVA, id: diva2:1651256
Note

Funding: The study was funded by the College of Research, Universityof Sharjah. Grant: Collaborative Research Project No. (15010902006-P).

Available from: 2022-04-11 Created: 2022-04-11 Last updated: 2022-04-20Bibliographically approved

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El-Serafi, Ahmed Taher

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