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The effect of vascular endothelial growth factor-1 expression on survival of advanced colorectal cancer patients
Department of Medical Oncology, University Sharjah Hospital, Sharjah, United Arab Emirates; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.ORCID iD: 0000-0002-5158-4590
College of Medicine, University of Sharjah, Sharjah, United Arab Emirates;Faculty of Medicine, Suez Canal University, Ismailia, Egypt.ORCID iD: 0000-0001-5394-9082
Turku University Hospital and University of Turku, Turku, Finland.
Turku University Hospital and University of Turku, Turku, Finland.
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2017 (English)In: Libyan Journal of Medicine, ISSN 1993-2820, E-ISSN 1819-6357, Vol. 12, no 1, article id 1290741Article in journal (Refereed) Published
Abstract [en]

Colorectal cancer is third leading cause of cancer mortality. About 60% of patients hadalready developed metastasis at the time of diagnosis. Vascular endothelial growth factor(VEGF) is crucial for the development of neovascularization and hence metastasis. This studyaimed at investigating the relation between the expression of VEGF in biopsies from surgically dissected colon cancer and the survival of those patients. Biopsies were collected from86 patients with advanced colon cancer and sections were stained by immunohistochemistryfor VEGF. Patients received chemotherapy after the operation and were followed up fordisease progression and survival. The clinical data were statistically analyzed with respectto the immunohistochemistry results. The survival of the patients was significantly longer inthe patients for whom biopsies showed negative or weak expression of VEGF in comparisonto those with moderate to high expression (p-value = 0.04). The expression of VEGF was morefrequent in the patients who died as a consequence of the disease in comparison to the 10-year survivors. In conclusion, VEGF could be related to the survival of the patients withcolorectal carcinoma and should be considered as a predictor of the prognosis.

Place, publisher, year, edition, pages
Abingdon, Oxfordshire, United Kingdom: Taylor & Francis, 2017. Vol. 12, no 1, article id 1290741
Keywords [en]
Vascular endothelial growth factor; colorectal cancer; survival; oncology; angiogenesis; chemoresistance
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:liu:diva-184452DOI: 10.1080/19932820.2017.1290741ISI: 000395981000001PubMedID: 28245709Scopus ID: 2-s2.0-85025660272OAI: oai:DiVA.org:liu-184452DiVA, id: diva2:1653285
Available from: 2022-04-21 Created: 2022-04-21 Last updated: 2022-05-11Bibliographically approved

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El-Serafi, Ahmed Taher

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Bendardaf, RiyadEl-Serafi, Ahmed Taher
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