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Dysregulation of male sex hormones in chronic hepatitis C patients
Faculty of Medicine, Suez Canal University, Ismaillia, Egypt; College of Medicine, University of Sharjah, Sharjah UAE.ORCID iD: 0000-0001-5394-9082
Faculty of Science, Port-Said University, Port-Said, Egypt.
Port-Said Tropical Hospital, Port-Said, Egypt.
Faculty of Science, Port-Said University, Port-Said, Egypt.
2016 (English)In: Andrologia, ISSN 0303-4569, E-ISSN 1439-0272, Vol. 48, no 1, p. 82-86Article in journal (Refereed) Published
Abstract [en]

Chronic hepatitis C (HCV) infection is a serious problem all over the world and has a special importance in Egypt, where the prevalence of infection is 14.7% of population. In males, HCV is associated with sexual dysfunction and changes in the semen parameters. This study aimed at estimation of a panel of the most important related hormones in the serum of patients and illustration of their correlation to the routine laboratory investigations. The four studied hormones showed alteration in the patients in comparison with the controls. While androstenedione, prolactin and testosterone were significantly increased in patients, dehydroepiandrosterone sulphate was decreased. These changes in the hormones were not related to the liver functions, pathological grade or even viral load. We hypothesised a model of how HCV can induce these hormonal changes and recommended to add these hormones to the follow-up panel of male patients with HCV.

Place, publisher, year, edition, pages
Berlin, Germany: Wiley-Blackwell, 2016. Vol. 48, no 1, p. 82-86
Keywords [en]
Androstenedione; dehydroepiandrosterone sulphate; hepatitis C; prolactin; testosterone
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-184454DOI: 10.1111/and.12425ISI: 000368087800012PubMedID: 25912488Scopus ID: 2-s2.0-84953638828OAI: oai:DiVA.org:liu-184454DiVA, id: diva2:1653301
Available from: 2022-04-21 Created: 2022-04-21 Last updated: 2022-04-28Bibliographically approved

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El-Serafi, Ahmed Taher

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CiteExportLink to record
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  • apa
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