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Comparison of the osteogenic differentiation potential of mesenchymal cells isolated from human bone marrow, umbilical cord blood and placenta derived stem cells
Medical Biochemistry Department, School of Medicine, Suez Canal University, Egypt.
Physiology Department, School of Medicine, Suez Canal University, Egypt.
Medical Biochemistry Department, School of Medicine, Suez Canal University, Egypt.
Physiology Department, School of Medicine, Suez Canal University, Egypt.
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2015 (English)In: Beni-Suef University Journal of Basic and Applied Sciences, ISSN 2314-8535, Vol. 4, no 1, p. 80-85Article in journal (Refereed) Published
Abstract [en]

Bone marrow has been considered for long time as the main source for mesenchymal stem cells. However, bone marrow aspiration is an invasive process that can be associated with morbidity as well as few numbers of obtained cells. Umbilical cord blood and placental tissues are other potential sources for the same type of cells. These sources are abundant, accessible and associated with no harm to the donor. This study aimed at determining the differentiation of the three cell types towards the osteogenic lineage in short term culture and in classical osteogenic conditions. The gene expression profile showed that bone marrow derived cells were the most responsive to the culture conditions while umbilical cord blood derived cells were next, as shown by the expression by the osteogenic key transcription factors ‘Runx-2’ and osterix. At the meantime, umbilical cord blood and placenta derived cells showed significant enhancement of the gene expression over the study course, which denoted potential response of the cells. Based on these results and the availability of these two sources, umbilical cord blood and placenta should still be considered as potential sources for mesenchymal stem cells in osteogenic research program. However their differentiation potential will need further enhancement.

Place, publisher, year, edition, pages
Heidelberg, Germany: Springer, 2015. Vol. 4, no 1, p. 80-85
Keywords [en]
Stem cells; Umbilical cord blood; Bone marrow; Placenta; Osteogenesis; Differentiation
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-184589DOI: 10.1016/j.bjbas.2015.02.011OAI: oai:DiVA.org:liu-184589DiVA, id: diva2:1654173
Available from: 2022-04-26 Created: 2022-04-26 Last updated: 2022-05-23Bibliographically approved

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El-Serafi, Ahmed Taher

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