liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effect of interleukin-6 and insulin resistance on early virological response of Egyptian chronic hepatitis C patients to combined pegylated interferon plus ribavirin therapy
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.ORCID iD: 0000-0002-0463-1518
Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.ORCID iD: 0000-0001-5394-9082
Show others and affiliations
2013 (English)In: Egyptian Liver Journal, ISSN 2090-6218, Vol. 3, no 2, p. 21-27Article in journal (Refereed) Published
Abstract [en]

Background and aim: Response to hepatitis C virus (HCV)-specific therapy is variable but might be influenced by host factors. We studied whether interleukin-6 (IL-6) level, IL-6–174G>C gene polymorphism, and insulin resistance affect the response to antiviral treatment in HCV-infected patients.

Patients and methods: Fifty-five chronic hepatitis C patients and 13 healthy individuals as controls were included in this study. Liver function tests, HCV RNA titer, ultrasonography, and histopathological examination of liver tissues were performed for all patients. Pretreatment plasma IL-6 levels and homeostasis model assessment-insulin resistance were estimated. The IL-6–174G>C polymorphism was detected by the PCR/RFLP method. After 12 weeks of combined pegylated interferon-α and ribavirin therapy, patients were classified into responders or nonresponders according to whether they achieved an early virological response.

Results: The responders had significantly high IL-6 levels (P=0.01), low mean stage of fibrosis (P=0.03), and low viral load (P=0.04) compared with nonresponders. Although not significant, patients with the IL-6–174 CC genotype reported a higher response rate (81%) compared with those with the CG genotype (50%) and GG genotype (62%). IL-6 level at a cutoff point of 2.15 pg/ml had 81.1% sensitivity and 72.7% specificity and showed significant relation with early virological response (P=0.04).

Conclusion: Estimation of basal IL-6 level could be used as a predictor of response to pegylated interferon-α and ribavirin therapy in CHC patients.

Place, publisher, year, edition, pages
Heidelberg, Germany: Wolters Kluwer, 2013. Vol. 3, no 2, p. 21-27
Keywords [en]
chronic hepatitis C; insulin resistance; interleukin-6; response to pegylated interferon-α and ribavirin
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-184598Scopus ID: 2-s2.0-84879368645OAI: oai:DiVA.org:liu-184598DiVA, id: diva2:1654193
Available from: 2022-04-26 Created: 2022-04-26 Last updated: 2022-05-04Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

ScopusLink to publication

Authority records

El Serafi, Ibrahim TaherEl Serafi, Ahmed Taher

Search in DiVA

By author/editor
El Serafi, Ibrahim TaherEl Serafi, Ahmed Taher
Infectious Medicine

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 36 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf