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In vivo dose-response analysis to acetylcholine: pharmacodynamic assessment by polarized reflectance spectroscopy
Linköping University, Department of Biomedical and Clinical Sciences, Division of Clinical Chemistry and Pharmacology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Emergency Medicine in Linköping.
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, ANOPIVA US. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.ORCID iD: 0000-0002-5903-2918
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Primary Care Center, Primary Health Care Center Åby.ORCID iD: 0000-0002-4245-7565
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-7299-891x
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 6594Article in journal (Refereed) Published
Abstract [en]

Transdermal iontophoresis offers an in vivo alternative to the strain-gauge model for measurement of vascular function but is limited due to lack of technical solutions for outcome assessment. The aims of this study were to, after measurement by polarized reflectance spectroscopy (PRS), use pharmacodynamic dose-response analysis on responses to different concentrations of acetylcholine (ACh); and to examine the effect of three consecutively administered iontophoretic current pulses. The vascular responses in 15 healthy volunteers to iontophorised ACh (5 concentrations, range 0.0001% to 1%, three consecutive pulses of 0.02 mA for 10 min each) were recorded using PRS. Data were fitted to a four-parameter logistic dose response model and compared. Vascular responses were quantifiable by PRS. Similar pharmacodynamic dose response curves could be generated irrespectively of the ACh concentration. Linearly increasing maximum vasodilatory responses were registered with increasing concentration of ACh. A limited linear dose effect of the concentration of ACh was seen between pulses. Polarized reflectance spectroscopy is well suited for measuring vascular responses to iontophoretically administrated ACh. The results of this study support further development of iontophoresis as a method to study vascular function and pharmacological responses in vivo.

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London, United Kingdom: Nature Publishing Group, 2022. Vol. 12, no 1, article id 6594
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URN: urn:nbn:se:liu:diva-185028DOI: 10.1038/s41598-022-10617-xISI: 000784878300039PubMedID: 35449189Scopus ID: 2-s2.0-85128631757OAI: oai:DiVA.org:liu-185028DiVA, id: diva2:1658907
Note

Funding Agencies: Linköping University; ALF grants; Region Östergotland, Linköping, Sweden [RO-726731]

Available from: 2022-05-18 Created: 2022-05-18 Last updated: 2022-09-15Bibliographically approved

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Henricson, JoakimSjöberg, FolkeIredahl, FredrikStrömberg, TomasBjörk Wilhelms, Daniel

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Division of Clinical Chemistry and PharmacologyFaculty of Medicine and Health SciencesDepartment of Emergency Medicine in LinköpingDivision of Prevention, Rehabilitation and Community MedicineANOPIVA USDepartment of Hand and Plastic SurgeryPrimary Health Care Center ÅbyDivision of Biomedical EngineeringFaculty of Science & Engineering
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