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Nanocellulose composite wound dressings for real-time pH wound monitoring
Linköping University, Department of Physics, Chemistry and Biology, Biophysics and bioengineering. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biophysics and bioengineering. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-3893-7777
Division of Materials Science, Department of Engineering Sciences and Mathematics, Luleå University of Technology, Luleå, Sweden.
Division of Materials Science, Department of Engineering Sciences and Mathematics, Luleå University of Technology, Luleå, Sweden.
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2023 (English)In: Materials Today Bio, ISSN 2590-0064, Vol. 19, article id 100574Article in journal (Refereed) Published
Abstract [en]

The skin is the largest organ of the human body. Wounds disrupt the functions of the skin and can have catastrophic consequences for an individual resulting in significant morbidity and mortality. Wound infections are common and can substantially delay healing and can result in non-healing wounds and sepsis. Early diagnosis and treatment of infection reduce risk of complications and support wound healing. Methods for monitoring of wound pH can facilitate early detection of infection. Here we show a novel strategy for integrating pH sensing capabilities in state-of-the-art hydrogel-based wound dressings fabricated from bacterial nanocellulose (BC). A high surface area material was developed by self-assembly of mesoporous silica nanoparticles (MSNs) in BC. By encapsulating a pH-responsive dye in the MSNs, wound dressings for continuous pH sensing with spatiotemporal resolution were developed. The pH responsive BC-based nanocomposites demonstrated excellent wound dressing properties, with respect to conformability, mechanical properties, and water vapor transmission rate. In addition to facilitating rapid colorimetric assessment of wound pH, this strategy for generating functional BC-MSN nanocomposites can be further be adapted for encapsulation and release of bioactive compounds for treatment of hard-to-heal wounds, enabling development of novel wound care materials.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 19, article id 100574
Keywords [en]
Bacterial nanocellulose, Wound dressing, pH sensor, Infection, Mesoporous silica nanoparticles
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:liu:diva-192408DOI: 10.1016/j.mtbio.2023.100574ISI: 000944392500001PubMedID: 36852226OAI: oai:DiVA.org:liu-192408DiVA, id: diva2:1743648
Note

Funding agencies: This work was supported by the Swedish Foundation for Strategic Research (SFF) grant no. FFL15-0026 and framework grant RMX18-0039 (HEALiX), the Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linköping University (Faculty Grant SFO-Mat-LiU no. 2009–00971), the competence center FunMat-II that is financially supported by Vinnova (grant no. 2016-05156), the Knut and Alice Wallenberg Foundation (grant no. KAW 2016.0231), the Swedish Research Council (VR) (grant no. 2021-04427) and Swedish strategic research program Bio4Energy. Illustrations were created with BioRender.com. We thank S2Medical AB, Linköping, Sweden, for providing BC.

Available from: 2023-03-15 Created: 2023-03-15 Last updated: 2024-05-01Bibliographically approved
In thesis
1. Multifunctional Nanocellulose Composite Materials
Open this publication in new window or tab >>Multifunctional Nanocellulose Composite Materials
2023 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Nanoparticles (NPs) are particles with more than one dimension between 1 and 100 nm. Because of their small size, they typically display different physical and chemical properties than the corresponding bulk materials. NPs have been used in many different applications, such as in electronics, optics, catalysis, and in biomedicine. Due to their colloidal nature, NPs are often immobilized on a solid substrate, such as glass or polymer-based materials, including biopolymers. Nanocellulose is a biopolymerbased nanomaterial that can be obtained from plants or bacterial biofilms. They can be processed into thin and highly hydrated films with high mechanical strength and can serve as a versatile substrate for NPs. Bacterial cellulose (BC) is also an interesting material for generating wound dressings. The combination of NPs and BC results in soft and flexible nanocomposites (BC-NPs) that can demonstrate novel properties and improve the functionality of wound dressings. 

BC-NP nanocomposites have previously been obtained by impregnating BC with the reactants needed for synthesis of the NPs and allowing the reaction to proceed in situ, inside and on the surface of the BC. This strategy limits the possibilities to control NP geometry and NP concentration and make synthesis of nanocomposites with more sophisticated compositions very challenging. In addition, the synthesis conditions used can potentially have negative effects on the properties of BC. 

The work presented in this thesis shows the possibility to produce well-defined, tunable BC-NP nanocomposites using self-assembly under very benign conditions that enable functionalization of BC with a wide range of different types of NPs. In addition to exploring the self-assembly process and the physical properties of these new BC-NP composites, several different applications were investigated. The functionalization of BC with gold nanoparticles (AuNPs) of different sizes and geometries was demonstrated. The resulting materials were used for development of a new sensor transduction technology, exploiting the optical response upon mechanical compression to detect biomolecules. BC-AuNP nanocomposites were also developed for monitoring of protease activity of wound pathogens, for catalysis, and for fabrication of ultra-black materials with unique absorption and scattering profiles of light in the visible and near infrared spectral range. In addition, the self-assembly process could be adopted for generating BC-mesoporous silica nanoparticles (MSNs) nanocomposite wound dressings. The resulting high surface area materials could be used as carriers for pH sensitive dyes. The pH-responsive BC-MSNs demonstrated adequate biocompatibility and allowed for monitoring of wound pH and for assessment of wound status. 

The strategies for functionalization of BC with inorganic NPs that was developed and explored in this thesis are highly versatile and allow for fabrication of a wide range of multifunctional nanocomposite materials. 

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2023. p. 60
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 2292
Keywords
nanomaterials, nanocomposites, bacterial cellulose, wound care, plasmonics, catalysis
National Category
Nano Technology Biophysics
Identifiers
urn:nbn:se:liu:diva-191590 (URN)10.3384/9789180750622 (DOI)9789180750615 (ISBN)9789180750622 (ISBN)
Public defence
2023-03-03, Nobel (BL32), B-huset, Campus Valla, Linköping, 13:15
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Supervisors
Available from: 2023-02-02 Created: 2023-02-02 Last updated: 2023-03-15Bibliographically approved

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Eskilson, OlofZattarin, ElisaRakar, JonathanSivlér, PetterSkog, MårtenShamasha, RozalinSotra, ZeljanaStarkenberg, AnnikaOdén, MagnusJunker, JohanSelegård, RobertBjörk, EmmaAili, Daniel

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Eskilson, OlofZattarin, ElisaHanna, KristinaRakar, JonathanSivlér, PetterSkog, MårtenRinklake, IvanaShamasha, RozalinSotra, ZeljanaStarkenberg, AnnikaOdén, MagnusJunker, JohanSelegård, RobertBjörk, EmmaAili, Daniel
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Biophysics and bioengineeringFaculty of Science & EngineeringDepartment of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesCenter for Disaster Medicine and TraumatologyDivision of Surgery, Orthopedics and OncologyNanostructured Materials
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