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Rendimiento diagnóstico de diferentes protocolos de estrés cardiaco usados en imagen de perfusión miocárdica para el diagnóstico de enfermedad coronaria usando una cámara de cadmio-zinc-telurio con correlación con angiografía coronaria [Diagnostic performance of different cardiac stress protocols for myocardial perfusion imaging for the diagnosis of coronary artery disease using a cadmium-zinc-telluride camera with invasive coronary angiography correlation]
Linköping University, Department of Health, Medicine and Caring Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart Center, Department of Clinical Physiology in Linköping. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Health, Medicine and Caring Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Clinical pathology.
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart Center, Department of Cardiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-3418-1706
Linköping University, Department of Health, Medicine and Caring Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart Center, Department of Clinical Physiology in Linköping. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
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2023 (Spanish)In: REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR, ISSN 2253-654X, Vol. 42, no 5, p. 281-288Article in journal (Refereed) Published
Abstract [en]

Purpose: To evaluate the diagnostic performance of three different cardiac stress protocols for myo-cardial perfusion imaging (MPI) using a cadmium-zinc-telluride (CZT) camera with invasive coronary angiography (ICA) correlation for the diagnosis of coronary artery disease in a high risk population. Methods: Retrospective study of 263 patients (96 women and 167 males, mean age 68 years) from which 119 patients performed a bicycle stress test (BST), 113 pharmacological stress test (PST) and 31 a com-bination of the two (CST) between September 2014 and December 2018. The patients then underwent myocardial perfusion imaging (MPI), followed by ICA and evaluated by means of quantitative angio-graphy software, within six months after the MPI. The mean pre-test probability score for coronary disease according to the European Society of Cardiology criteria was 36% for the whole population. The MPI was performed in a dedicated CZT cardio camera (D-SPECT Spectrum Dynamics) with a two-day protocol, according to the European Association of Nuclear Medicine guidelines.Results: No significant difference was observed between the three stress protocols in terms of diagnostic accuracy (BST 85%, PST 88% and CST 84%). The overall diagnostic accuracy of MPI to identify patients with any obstructive CAD at ICA was 86%, Sensitivity 93%, Specificity 54%, PPV 90% and NPV 63%.Conclusion: The CZT D-SPECT camera achieves overall satisfactory results in the diagnosis of CAD, obser-ving no significant differences in the diagnostic performance when the stress test was performed as a BST, PST or CST.& COPY; 2023 Sociedad Espanola de Medicina Nuclear e Imagen Molecular. Published by Elsevier Espana, S.L.U. All rights reserved.

Abstract [es]

ObjetivoEvaluar el rendimiento diagnóstico de tres protocolos diferentes de estrés cardiaco utilizados en imagen de perfusión miocárdica (IPM), usando una cámara de cadmio-zinc-telurio (CZT) en correlación con angiografía coronaria (AC) para el diagnóstico de enfermedad arterial coronaria (EAC) en una población de alto riesgo.MétodosEstudio retrospectivo realizado en 263 pacientes (96 mujeres y 167 varones, edad media 68 años), de los cuales 119 realizaron una prueba de estrés con bicicleta (PEB), 113 una prueba de estrés farmacológica (PEF) y 31 una combinación de ambas (PEC), entre septiembre de 2014 y diciembre de 2018. Posteriormente realizaron una IPM, seguida de AC dentro de los seis meses posteriores a la IPM. La probabilidad preprueba media para EAC según los criterios de la Sociedad Europea de Cardiología fue de 36%. La IPM se realizó en una cámara CZT cardio dedicada (D-SPECT Spectrum Dynamics) con un protocolo de dos días, de acuerdo con las guías de la Asociación Europea de Medicina Nuclear (EANM).ResultadosNo se observaron diferencias significativas entre los diferentes protocolos de estrés en términos de precisión diagnóstica (PEB 85%, PEF 88%, PEC 84%). La exactitud diagnóstica general de IPM para identificar pacientes con cualquier EAC obstructiva en AC fue de 86%, sensibilidad de 93%, especificidad de 54%, VPP de 90% y VPN de 63%.ConclusiónLa cámara CZT D-SPECT logra resultados generales satisfactorios en el diagnóstico de la EAC, sin encontrar diferencias significativas en el rendimiento diagnóstico cuando la prueba de esfuerzo se realizó como PEB, PEF o PEC.

Place, publisher, year, edition, pages
ELSEVIER ESPANA SLU , 2023. Vol. 42, no 5, p. 281-288
Keywords [en]
Bicycle exercise; Regadenoson; Myocardial scintigraphy; Cadmium-zinc-telluride; Coronary angiography; Coronary artery disease
Keywords [es]
Ejercicio en bicicleta; Regadenosón; Gammagrafía cardiaca; Cadmio-zinc-telurio; Angiografía coronaria; Enfermedad coronaria
National Category
Cardiology and Cardiovascular Disease
Identifiers
URN: urn:nbn:se:liu:diva-198522DOI: 10.1016/j.remn.2022.01.001ISI: 001073976300001PubMedID: 36103979OAI: oai:DiVA.org:liu-198522DiVA, id: diva2:1805557
Available from: 2023-10-17 Created: 2023-10-17 Last updated: 2025-02-10

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Ochoa-Figueroa, MiguelFrias Rose, Miguel JeronimoGood, ElinSanchez-Rodriguez, V.Davidsson, AnettePagonis, Christos
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Department of Health, Medicine and Caring SciencesFaculty of Medicine and Health SciencesDepartment of Clinical Physiology in LinköpingDepartment of Radiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)Clinical pathologyDivision of Diagnostics and Specialist MedicineDepartment of Cardiology in Linköping
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