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Multidisciplinary team meetings improve survival in patients with esophageal cancer
Karolinska Inst, Sweden.
Uppsala Univ, Sweden.
Lund Univ, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.ORCID iD: 0000-0003-2172-5310
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2024 (English)In: Diseases of the esophagus, ISSN 1120-8694, E-ISSN 1442-2050, Vol. 37, no 11, article id doae061Article in journal (Refereed) Published
Abstract [en]

Multidisciplinary team meetings (MDTs) are recommended for patients with esophageal cancer. Improved staging, timeliness to surgery and better adherence to guidelines have been attributed to MDTs, but there are few studies published on the MDTs' effect on survival. All patients with esophageal cancer in Sweden between 2006 and 2018 were grouped according to whether they had been discussed at an MDT as part of their clinical pathway. Factors affecting group allocation were explored with multivariable logistic regression, and the impact of MDT on survival was studied with Cox-regression and the Kaplan-Meier estimator. Of 6837 included patients, 1338 patients (20%) were not discussed at an MDT. Advanced age (80-90 years; odds ratio [OR] 0.25, 0.16-0.42 (95% confidence interval)) and clinical stage IVb (OR 0.65, 0.43-0.98) decreased the probability of being presented at an MDT, whereas high education level (OR 1.31, 1.02-1.67), being married (OR 1.20, 1.01-1.43), squamous histology (OR 1.50, 1.22-1.84) and later year of diagnosis (OR 1.33, 1.29-1.37 per year) increased the probability of an MDT. In multivariable adjusted analysis, MDT discussion was associated with improved survival (hazard ratios 0.72, 0.66-0.78) and median survival increased from 4.5 to 10.7 months. MDTs were associated with improved survival for esophageal cancer patients. Elderly patients with advanced disease and poor socioeconomic status were less likely to be presented at an MDT, but had clear survival-benefits if they were discussed in a multidisciplinary setting.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS INC , 2024. Vol. 37, no 11, article id doae061
Keywords [en]
cancer; esophageal; survival
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-207189DOI: 10.1093/dote/doae061ISI: 001286565000001PubMedID: 39119871OAI: oai:DiVA.org:liu-207189DiVA, id: diva2:1895560
Note

Funding Agencies|Ihre Foundation

Available from: 2024-09-06 Created: 2024-09-06 Last updated: 2025-04-18Bibliographically approved

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Edholm, David

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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Surgery in Linköping
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