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Långvarig förskrivning av opioidläkemedel – en komplex situation. Nedtrappningens plats i den kliniska handläggningen. [To taper or not to taper opioids – that is the question.]
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.ORCID iD: 0000-0003-4420-418X
Smärtcentrum/Anopiva Östra, Sahlgrenska universitetssjukhuset, Göteborg, Sverige.
Smärt­rehabilitering, Skånes universitetssjukhus Lund, Sverige.
Smärt­centrum, Sahlgrenska universitetssjukhuset, Göteborg, Sverige.
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2025 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 122, article id 24143Article in journal (Refereed) Published
Abstract [sv]

Långvarig förskrivning av opioidläkemedel är en komplex klinisk situation där indikationen långvarig icke-malign smärta är mindre önskvärd men ändå förekommer.

Problematisk användning av opioider eller utvecklande av opioidbrukssyndrom förekommer i populationen. 

Nedtrappning med planerat stöd och uppföljning är en medicinsk intervention som bör övervägas.

Potentiella fördelar inkluderar ökad patientsäkerhet, reversering av biverkningar och en förbättrad helhetssituation.

Risker inkluderar akuta och långvariga abstinenssymtom samt försämrad psykisk hälsa.

Abstract [en]

There is a lack of evidence for long-term opioid treatment of chronic non-cancer pain. According to European guidelines, opioids should not be used for primary chronic pains.  It is important to continuously assess the benefits and harms of each opioid treatment and, if indicated, discontinue it as early as possible to prevent an adverse trajectory. Long-term opioid treatment is a clinically complex situation in which the issue of tapering (deprescribing) should be considered. Tapering is a medical intervention that entails planned support and close follow-up. Potential benefits include increased safety, reversal of side effects, and an improved overall situation. Risks include acute and protracted withdrawal symptoms (including worsening pain) and impaired mental health. Problematic use of opioids (including opioid use disorder) occurs in this population, but prescribers should avoid a stereotypical and stigmatizing attitude.

Place, publisher, year, edition, pages
Läkartidningen Förlag AB , 2025. Vol. 122, article id 24143
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Clinical Medicine
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URN: urn:nbn:se:liu:diva-222020OAI: oai:DiVA.org:liu-222020DiVA, id: diva2:2046462
Available from: 2026-03-17 Created: 2026-03-17 Last updated: 2026-06-08

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Bäckryd, EmmanuelKallman, Thomas F.

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Division of Prevention, Rehabilitation and Community MedicineFaculty of Medicine and Health SciencesPain and Rehabilitation CenterClinical Department of Pain and Rehabilitation Medicine
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