The discrepancy between wall thickness, myocardial mass, and ECG appearances in young patients with cardiomyopathies
2025 (English)In: Electrocardiographic Left Ventricular Hypertrophy: Looking Beyond Left Ventricular Mass, Elsevier , 2025, p. 103-123Chapter in book (Other academic)
Abstract [en]
This chapter surveys the role of electrocardiography (ECG) in disease diagnosis, disease monitoring, and risk stratification in children and young adults with cardiomyopathy. In hypertrophic cardiomyopathy (HCM), left ventricular (LV) mass measured by magnetic resonance imaging correlates best with ECG measures when indexed to body surface area, with the 12-lead QRS amplitude-duration product (12-lead prod) having a correlation coefficient of 0.70 with total LV mass (p<0.0001), and 0.77 with LV mass indexed to body surface area (p<0.0001). Extreme values of 12-lead prod often signal unusual molecular etiology. In individual patients, changes in 12-lead prod follow changes in LV mass estimates well. In dilated cardiomyopathy (DCM), the LV mass lacks a significant correlation with 12-lead prod, but gradual reduction in voltages and broadening of QRS complex indicate progression of disease. Risk stratification for sudden death based on ECG measures for HCM (https://www.ecgriskscore.org) or a mixture of ECG and clinical parameters in other cardiomyopathies (DCM-SVA risk and https://arvcrisk.com/) is reviewed.
Place, publisher, year, edition, pages
Elsevier , 2025. p. 103-123
Keywords [en]
arrhythmogenic cardiomyopathy, dilated cardiomyopathy, electrocardiography, Hypertrophic cardiomyopathy, left ventricular mass, risk factors, sudden cardiac death, Cardiology, Lead compounds, Risk assessment, Body surface, Cardiac death, Risk stratification, Surface area
National Category
Cardiology and Cardiovascular Disease
Identifiers
URN: urn:nbn:se:liu:diva-222937DOI: 10.1016/B978-0-443-33927-1.00009-2Scopus ID: 2-s2.0-105027107276ISBN: 9780443339271 (print)ISBN: 9780443339288 (electronic)OAI: oai:DiVA.org:liu-222937DiVA, id: diva2:2053345
Note
Book chapter; Export Date: 16 April 2026; Cited By: 0
2026-04-162026-04-162026-04-16