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The discrepancy between wall thickness, myocardial mass, and ECG appearances in young patients with cardiomyopathies
Division of Pediatrics, Göteborgs Universitet, Gothenburg, Västra Götaland, Sweden, Pediatric Heart Center, Drottning Silvias Barnsjukhus, Gothenburg, Västra Götaland, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Children's and Women's Health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.
Pediatric Heart Center, Drottning Silvias Barnsjukhus, Gothenburg, Västra Götaland, Sweden, Department of Molecular and Clinical Medicine, Sahlgrenska Akademin, Gothenburg, Västra Götaland, Sweden.
2025 (English)In: Electrocardiographic Left Ventricular Hypertrophy: Looking Beyond Left Ventricular Mass, Elsevier , 2025, p. 103-123Chapter in book (Other academic)
Abstract [en]

This chapter surveys the role of electrocardiography (ECG) in disease diagnosis, disease monitoring, and risk stratification in children and young adults with cardiomyopathy. In hypertrophic cardiomyopathy (HCM), left ventricular (LV) mass measured by magnetic resonance imaging correlates best with ECG measures when indexed to body surface area, with the 12-lead QRS amplitude-duration product (12-lead prod) having a correlation coefficient of 0.70 with total LV mass (p<0.0001), and 0.77 with LV mass indexed to body surface area (p<0.0001). Extreme values of 12-lead prod often signal unusual molecular etiology. In individual patients, changes in 12-lead prod follow changes in LV mass estimates well. In dilated cardiomyopathy (DCM), the LV mass lacks a significant correlation with 12-lead prod, but gradual reduction in voltages and broadening of QRS complex indicate progression of disease. Risk stratification for sudden death based on ECG measures for HCM (https://www.ecgriskscore.org) or a mixture of ECG and clinical parameters in other cardiomyopathies (DCM-SVA risk and https://arvcrisk.com/) is reviewed.

Place, publisher, year, edition, pages
Elsevier , 2025. p. 103-123
Keywords [en]
arrhythmogenic cardiomyopathy, dilated cardiomyopathy, electrocardiography, Hypertrophic cardiomyopathy, left ventricular mass, risk factors, sudden cardiac death, Cardiology, Lead compounds, Risk assessment, Body surface, Cardiac death, Risk stratification, Surface area
National Category
Cardiology and Cardiovascular Disease
Identifiers
URN: urn:nbn:se:liu:diva-222937DOI: 10.1016/B978-0-443-33927-1.00009-2Scopus ID: 2-s2.0-105027107276ISBN: 9780443339271 (print)ISBN: 9780443339288 (electronic)OAI: oai:DiVA.org:liu-222937DiVA, id: diva2:2053345
Note

Book chapter; Export Date: 16 April 2026; Cited By: 0

Available from: 2026-04-16 Created: 2026-04-16 Last updated: 2026-04-16

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Publisher's full textScopusFind book at a Swedish library/Hitta boken i ett svenskt bibliotek

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Fernlund, EvaWålinder Österberg, Anna

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Fernlund, EvaWålinder Österberg, Anna
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesH.K.H. Kronprinsessan Victorias barn- och ungdomssjukhusDivision of Children's and Women's Health
Cardiology and Cardiovascular Disease

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