In spite of many years of research, it appears that there is no commonly accepted understanding of central concepts in organizational discourse such as “knowledge”, “integration”, “coordination”, or for that matter, “organization” itself. The purpose of this contribution is to elucidate these issues with the help of the Activity Domain Theory (ADT). This theory is based on a simple idea: human action is made possible by innate human dispositions that are sculptured in social contexts. Coordination is enabled by certain inherent faculties called the activity modalities: contextualization, spatialization, temporalization, stabilization, and transition. I describe these and other features of the ADT, and provide some examples from the Ericsson development practice, which is where the ADT originated. In addition, I discuss knowledge integration and innovation management from the perspective of the ADT. I conclude that the line of inquiry suggested by the ADT may be well worth to pursue in future research.