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No time to waste: Pre-hospital actions and time delays in patients with ST elevation myocardial infarction – temporal trends and prognostic impact on short- and long-term survival
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart Center, Department of Cardiology in Linköping.
2022 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Background: In ST-elevation myocardial infarction (STEMI) patients, a rapid diagnosis is imperative to reduce total ischaemic time minimizing risk for heart failure, serious arrhythmias, or death. Prehospital context is complex, and the patient delay constitute major part of the pre-hospital phase. Patient delay has been prone hard to impact but the system delay has had major transformation during the years.  

Aim: The overall aim was to explore pre-hospital actions and time delays in STEMI patients, investigating temporal trends and estimate prognostic impact on short- and long-term survival.  

Methods: Study I, was a multicentre survey study, exploring decisions, and actions in relation to the choice of first medical contact (FMC). Study II was a sub-study to the multicentre survey, exploring the interaction between tele nurses and callers in authentic calls when the caller with an evolving myocardial infarction (MI) chose to call Swedish health care direct (SHD) as FMC. Study III, was based on the same database as study I, exploring early (< 20 minutes) and late (> 90 minutes) response from symptom onset in STEMI patients. Study IV, was based on SWEDEHEART-registry, investigating temporal trends in pre-specified risk groups for pro-longed pre-hospital delay times (PHDT), estimating cumulative survival in short and long term stratified in six different PHDT groups.  

Results: Study I, only half of the patients’ contacted emergency medical services (EMS) as their FMC. Choice of FMC prolonged time to diagnosis in relation of calling EMS. Choosing SHD pro-longed delay to diagnosis with 38 minutes. Study II, four interactions were found between tele-nurses and callers, reasoning, distinct, irrational, and indecisive, and type of interaction could lead or mislead the call moving progressively forward or not. Study III, bystanders calling EMS, men, intensive and alarming symptoms such as dyspnoea and weakness and to interpret symptoms attributed from the heart was associated with a rapid action calling an ambulance within 20 minutes, which was performed by one of five patients. Study IV, trend curves for median PHDT was hump shaped for the 20 years studied. Women, older age, and patients with diabetes had consistent pro-longed PHDT, except for the oldest patients (> 80 years). PHDT was an independent risk for short- and long-term survival. Patients with the shortest PHDT 0-1 hour had the highest mortality up to five days. In five-year follow up this group accompanied with the group within 1-2 hours had highest estimated survival.  

Conclusion: Pre-hospital delay is an independent predictor of short- and long-term survival. To interpret symptom correctly and knowledge in how to act, calling an ambulance rapidly, impact time to diagnosis and diminish time delays. Pre-hospital delay merits further attention regarding future interventions.  

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2022. , p. 83
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1808
National Category
Cardiology and Cardiovascular Disease
Identifiers
URN: urn:nbn:se:liu:diva-183386ISBN: 9789179292751 (print)ISBN: 9789179292768 (electronic)OAI: oai:DiVA.org:liu-183386DiVA, id: diva2:1642539
Public defence
2022-04-01, Berzeliussalen Building 463, Campus US, Linköping, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2022-03-07 Created: 2022-03-07 Last updated: 2025-02-10Bibliographically approved
List of papers
1. First medical contact in patients with STEMI and its impact on time to diagnosis; an explorative cross-sectional study
Open this publication in new window or tab >>First medical contact in patients with STEMI and its impact on time to diagnosis; an explorative cross-sectional study
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2015 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 5, no 4, p. e007059-Article in journal (Refereed) Published
Abstract [en]

Objective: It is unknown into what extent patients with ST-elevation myocardial infarction (STEMI) utilise a joint service number (Swedish Healthcare Direct, SHD) as first medical contact (FMC) instead of Emergency Medical Services (EMS) and how this impact time to diagnosis. We aimed to (1) describe patients FMC; (2) find explanatory factors influencing their FMC (ie, EMS and SHD) and (3) explore the time interval from symptom onset to diagnosis. Setting: Multicentred study, Sweden. Methods: Cross-sectional, enrolling patients with consecutive STEMI admitted within 24 h from admission. Results: We included 109 women and 336 men (mean age 66 +/- 11 years). Although 83% arrived by ambulance to the hospital, just half of the patients (51%) called EMS as their FMC. Other utilised SHD (21%), contacted their primary healthcare centre (14%), or went directly to the emergency room (14%). Reasons for not contacting EMS were predominantly; (1) my transport mode was faster (40%), (2) did not consider myself sick enough (30%), and (3) it was easier to be driven or taking a taxi (25%). Predictors associated with contacting SHD as FMC were female gender (OR 1.92), higher education (OR 2.40), history of diabetes (OR 2.10), pain in throat/neck (OR 2.24) and pain intensity (OR 0.85). Predictors associated with contacting EMS as FMC were history of MI (OR 2.18), atrial fibrillation (OR 3.81), abdominal pain (OR 0.35) and believing the symptoms originating from the heart (OR 1.60). Symptom onset to diagnosis time was significantly longer when turning to the SHD instead of the EMS as FMC (1: 59 vs 1: 21 h, pless than0.001). Conclusions: Using other forms of contacts than EMS, significantly prolong delay times, and could adversely affect patient prognosis. Nevertheless, having the opportunity to call the SHD might also, in some instances, lower the threshold for taking contact with the healthcare system, and thus lowers the number that would otherwise have delayed even longer.

Place, publisher, year, edition, pages
BMJ Publishing Group: Open Access / BMJ Journals, 2015
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-119268 (URN)10.1136/bmjopen-2014-007059 (DOI)000354705000054 ()25900460 (PubMedID)
Note

Funding Agencies|Medical Research Council of Southeast Sweden (FORSS) [161061]

Available from: 2015-06-12 Created: 2015-06-12 Last updated: 2023-08-28
2. Interaction between tele-nurses and callers with an evolving myocardial infarction: Consequences for level of directed care
Open this publication in new window or tab >>Interaction between tele-nurses and callers with an evolving myocardial infarction: Consequences for level of directed care
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2019 (English)In: European Journal of Cardiovascular Nursing, ISSN 1474-5151, E-ISSN 1873-1953, Vol. 18, no 7, p. 545-553Article in journal (Refereed) Published
Abstract [en]

Background: Rapid contact with emergency medical services is imperative to save the lives of acute myocardial infarction patients. However, many patients turn to a telehealth advisory nurse instead, where the delivery of urgent and safe care largely depends on how the interaction in the call is established. Purpose: The purpose of this study was to explore the interaction between tele-nurses and callers with an evolving myocardial infarction after contacting a national telehealth advisory service number as their first medical contact. Method: Twenty men and 10 women (aged 46-89 years) were included. Authentic calls were analysed using inductive content analysis. Findings: One overall category, Movement towards directed level of care, labelled the whole interaction between the tele-nurse and the caller. Four categories conceptualised the different interactions: a distinct, reasoning, indecisive or irrational interaction. The interactions described how tele-nurses and callers assessed and elaborated on symptoms, context and actions. The interaction was pivotal for progress in the dialogue and affected the achievement of mutual understanding in the communicative process. An indecisive or irrational interaction could increase the risk of failing to recommend or call for acute care. Conclusion: The interaction in the communication could either lead or mislead the level of care directed in the call. This study adds new perspectives to the communicative process in the acute setting in order to identify a myocardial infarction and the level of urgency from both individuals experiencing myocardial infarction and professionals in the health system.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD, 2019
Keywords
Pre-hospital care-seeking; interaction; level of care; myocardial infarction; tele-nursing
National Category
Nursing
Identifiers
urn:nbn:se:liu:diva-160988 (URN)10.1177/1474515119848195 (DOI)000487801400004 ()31067981 (PubMedID)
Available from: 2019-11-04 Created: 2019-11-04 Last updated: 2022-03-07
3. Factors associated with patient decision time in ST-segment elevation myocardial infarction, in early and late responders—an observational cross-sectional survey study
Open this publication in new window or tab >>Factors associated with patient decision time in ST-segment elevation myocardial infarction, in early and late responders—an observational cross-sectional survey study
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2022 (English)In: European Journal of Cardiovascular Nursing, ISSN 1474-5151, E-ISSN 1873-1953, Vol. 21, no 7, p. 694-701Article in journal (Refereed) Published
Abstract [en]

Aims A short time span from symptom onset to reperfusion is imperative in ST-segment elevation myocardial infarction (STEMI). The aim of this study was to determine factors associated with patient decision time for seeking care in STEMI, particularly how symptoms were experienced and affected patient response. Methods and results A multicentre cross-sectional self-report survey study was completed at five Swedish hospitals representing geographic diversity. The 521 patients were divided into three groups based on their time to respond to symptoms: early (<20 min), intermediate (20-90 min), and late responders (>90 min). Only one out of five patients both responded early and called an ambulance within 20 min. Believing symptoms were cardiac in origin [odds ratio (OR) 2.60], male sex (OR 2.40), left anterior descending artery as culprit artery (OR 1.77), and bystanders calling an ambulance (OR 4.32) were factors associated with early response and correct action. Associated symptoms such as dyspnoea (OR 1.67) and weakness (OR 1.65) were associated with an early action (<20 min), while chest pain was not independently associated with response time. Cold sweat (OR 0.61) prevented late care-seeking behaviour as did a high symptom burden (OR 0.86). Conclusion Misinterpretation of symptoms delays correct care-seeking behaviour because patient expectations may not be aligned with the experience when stricken by Myocardial infarction. Therefore, it is imperative to continuously enhance public awareness in correct symptom recognition and appropriate care-seeking behaviour and to make efforts to educate individuals at risk for STEMI as well as their next of kin.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS, 2022
Keywords
Acute coronary syndrome, Decision-making, Care seeking, Pre-hospital delay, Symptom recognition, Symptom response
National Category
Cardiology and Cardiovascular Disease
Identifiers
urn:nbn:se:liu:diva-183381 (URN)10.1093/eurjcn/zvab124 (DOI)000764519500001 ()35165735 (PubMedID)
Note

Funding agencies: The Medical Research Council of Southeast Sweden (FORSS), Region Östergötland, Sweden, and Linköping University Hospital Research Fund, Sweden.

Available from: 2022-03-07 Created: 2022-03-07 Last updated: 2025-02-10

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