Prototyping and Early Validation of an Integrated, Electrochemical and Mass Three-sensor Array for Dengue DetectionShow others and affiliations
2021 (English)In: PROCEEDINGS OF THE 15TH INTERNATIONAL JOINT CONFERENCE ON BIOMEDICAL ENGINEERING SYSTEMS AND TECHNOLOGIES (BIODEVICES), VOL 1, SCITEPRESS , 2021, p. 204-211Conference paper, Published paper (Refereed)
Abstract [en]
This paper presents the current progress towards a lab-on-chip biosensor for early dengue detection, consisting of an integrated sensor with dual-function working electrode that enables in-situ measurements of both electrochemical impedance spectroscopy (EIS) and quartz crystal microbalance (QCM) enclosed in a miniaturized 3D-printed package equipped with electrical contacts and sample fluid delivery to the quartz biosensor array. The sensors consist of an array of three 10 MI-lz IEQCM biosensors on a single quartz substrate. Early validation is performed for future dengue sensing application. We report the design, optimisation, and fabrication of the sensors, as well as early optimisation and validation of surface bioconjugation of antibodies. This lab-on-chip has the potential to provide accurate dengue detection due to its high sensitivity and dynamic range, as well as providing rapid and early dengue detection in point-of-care settings.
Place, publisher, year, edition, pages
SCITEPRESS , 2021. p. 204-211
Keywords [en]
Dengue; Biosensor; Sensor Arrays; Integrated Electrochemical-Quartz Crystal Microbalance; Point-of-Care Diagnostics
National Category
Medical Laboratory Technologies
Identifiers
URN: urn:nbn:se:liu:diva-184569DOI: 10.5220/0010961500003123ISI: 000778905500024ISBN: 9789897585524 (print)OAI: oai:DiVA.org:liu-184569DiVA, id: diva2:1655363
Conference
15th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC) / 15th International Conference on Biomedical Electronics and Devices (BIODEVICES), ELECTR NETWORK, feb 09-11, 2022
Note
Funding Agencies|Swedish Research CouncilSwedish Research CouncilEuropean Commission [2014-4254]; Malaysian Ministry of Higher Education [FRGS15-217-0458]; French National Research Agency under the Investments for the Future programFrench National Research Agency (ANR) [ANR-10-LABX-0074-01]
2022-05-022022-05-022025-02-09