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Review of the effects of polycystic ovary syndrome on Cognition: Looking beyond the androgen hypothesis
Univ Toronto, Canada; Univ Toronto, Canada.
Univ Toronto, Canada; Univ Illinois, IL USA.
Linköping University, Department of Thematic Studies, The Department of Gender Studies. Linköping University, Faculty of Arts and Sciences. Univ Toronto, Canada; Univ Toronto, Canada; Baycrest Hosp, Canada.ORCID iD: 0000-0002-0770-5471
2022 (English)In: Frontiers in Neuroendocrinology, ISSN 0091-3022, E-ISSN 1095-6808, Vol. 67, article id 101038Article, review/survey (Refereed) Published
Abstract [en]

Polycystic-ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age, and many features associated with PCOS - such as elevated androgens, insulin resistance and inflammation - are known to affect cognition. However, effects of PCOS on cognition are not well-understood. Here we review the current literature on PCOS and cognition, note the extent of PCOS symptomatology studied in relation to cognitive outcomes, and identify key research gaps and common methodological concerns. Findings indicate a pattern of worse performance across cognitive domains and brain measures in women with PCOS relative to nonPCOS controls, as well as a lack of evidence for the common assumption that women with PCOS will have higher performance on tasks with a demonstrated male-advantage due to high testosterone levels. We suggest strategies for moving beyond the focus on elevated androgens, in favor of research practices that account for the nuances and heterogeneity of PCOS symptoms.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2022. Vol. 67, article id 101038
Keywords [en]
Polycystic ovary syndrome; PCOS; Cognition; Insulin resistance; Testosterone; Sex hormones; Women ?s health; Cognitive function; Review
National Category
Psychology (excluding Applied Psychology)
Identifiers
URN: urn:nbn:se:liu:diva-189954DOI: 10.1016/j.yfrne.2022.101038ISI: 000876416400001PubMedID: 36154816OAI: oai:DiVA.org:liu-189954DiVA, id: diva2:1711043
Note

Funding Agencies|Ontario Graduate Scholarship-International; Jacqueline Ford Gender and Health Fund; Wilfred and Joyce Posluns Chair in Womens Brain Health and Aging from the Posluns Family Foundation; Womens Brain Health Initiative; Canadian Institutes of Health Research; Alzheimers Society of Canada; Ontario Brain Institute [WJP-150643]

Available from: 2022-11-15 Created: 2022-11-15 Last updated: 2023-02-08

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Citation style
  • apa
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