For millennia humans have interacted with a range of chemical substances that are an inte-gral part of human history and culture. The chemical characteristics of the three similar-looking chemical species psilocybin, nicotine, and caffeine have remarkably different biological effects. The narratives of these chemical characters are compelling—their role traverses the unobservable submicro-scopic world, influences our biological essence, and impacts societal values and sci-entific judgement. Visual storytelling through modern display technologies offers an educa-tional method to communicate the nature and effect of these chemical actors. Biological information that transcends multi-directionally and constantly from submicroscopic through to macroscopic processes can be made acces-sible and meaningful to students and the pub-lic. In doing so, links are forged between scientific knowledge and the manner we view these chemical forms from a human and socie-tal context. In attempting to capture these complexities, the aim of this chapter is to con-ceptualise and design a visual story to commu-nicate the effect of psilocybin, nicotine, and caffeine on humans for public engagement. Whilst remarkably similar in chemical struc-ture, these chemical species have dramatically different psychological and physiological effects on the human body. At the same time, human interaction with these substances is intertwined with historical associations, cul-tural norms, as well as perceived and enacted taboos.