This paper aims to present challenges of quality management in cross-cultural settings and suggest possible handling strategies for quality managers based on a multiple case study. The result suggests that management leadership, employee engagement and empowerment, and continuous improvement are the QM values affected the most by national culture of subsidiaries. However, the degrees of discrepancy depend on the strength of organizational culture. Hence, the suggested handling strategy is to educate employees with standardized QM techniques and tools to establish means and measures for QM values that are promoted via strong organizational culture focusing on quality and customers.