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The risky business of ADP-ribosylating telomeric DNA
IFOM ETS The AIRC Inst Mol Oncol, Italy.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-0677-8986
2024 (English)In: Nature Structural & Molecular Biology, ISSN 1545-9993, E-ISSN 1545-9985, Vol. 31, no 5, p. 737-738Article in journal, Editorial material (Refereed) Published
Abstract [en]

ADP-ribosylation regulates the activity of numerous proteins involved in the DNA damage response and repair. A new study shows that telomeric DNA can be ADP-ribosylated by PARP1, and prompt removal of the ADP-ribose by TARG1 is essential to preserve telomere integrity, unveiling DNA-ADP-ribosylation as a novel player in telomere stability.
Place, publisher, year, edition, pages
NATURE PORTFOLIO , 2024. Vol. 31, no 5, p. 737-738
National Category
Biochemistry Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-203567DOI: 10.1038/s41594-024-01285-8ISI: 001215389000001PubMedID: 38714888Scopus ID: 2-s2.0-85192272092OAI: oai:DiVA.org:liu-203567DiVA, id: diva2:1858965
Note

Funding Agencies|Knut and Alice Wallenberg Foundation (KAW); CancerFonden; Vetenskapsrdet

Available from: 2024-05-20 Created: 2024-05-20 Last updated: 2025-08-18Bibliographically approved

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Lottersberger, Francisca

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