Despite extensive research on academic entrepreneurship and entrepreneurial universities, this special issue challenges conventional beliefs by examining intrapreneurship in academia. It aims to investigate how faculty and staff can adopt entrepreneurial behaviors and cultivate an entrepreneurial approach within their roles as researchers and educators, in diverse academic contexts. The 11 papers included in this issue span various domains of intrapreneurial universities, broadening the original concept beyond initial expectations set forth in the call for papers. Exploring a spectrum of intrapreneurial initiatives, this issue seeks to enhance understanding and broaden perspectives on intrapreneurial behaviors within universities through various research approaches and methodologies. Based on the contributions received, we reflect on theoretical and practical implications and delineate future directions for academic intrapreneurship research.