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Frailty is associated with 30-day mortality: a multicentre study of Swedish emergency departments
Linköping University, Department of Biomedical and Clinical Sciences, Division of Clinical Chemistry and Pharmacology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Emergency Medicine in Linköping.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Clinical Chemistry and Pharmacology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Emergency Medicine in Linköping.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Clinical Chemistry and Pharmacology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Emergency Medicine in Linköping.ORCID iD: 0000-0001-9299-5428
Linköping University, Department of Biomedical and Clinical Sciences, Division of Clinical Chemistry and Pharmacology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Emergency Medicine in Linköping.
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2024 (English)In: Emergency Medicine Journal, ISSN 1472-0205, E-ISSN 1472-0213, Vol. 41, no 9, p. 514-519Article in journal (Refereed) Published
Abstract [en]

Background Older patients living with frailty have an increased risk for adverse events. The Clinical Frailty Scale (CFS) is a 9-point frailty assessment instrument that has shown promise to identify frail emergency department (ED) patients at increased risk of adverse outcomes. The aim of this study was to investigate the association between CFS scores and 30-day mortality in an ED setting when assessments are made by regular ED staff.Method This was a prospective multicentre observational study carried out between May and November 2021 at three EDs in Sweden, where frailty via CFS is routinely assessed by ED staff. All patients >= 65 years of age were eligible for inclusion. Mortality at 7, 30 and 90 days, admission rate, ED and hospital length of stay (LOS) were compared between patients living with frailty (CFS >= 5) and robust patients. Logistic regression was used to adjust for confounders.Results A total of 1840 ED visits of patients aged >= 65 years with CFS assessments done during the study period were analysed, of which 606 (32.9%) were patients living with frailty. Mortality after the index visit was higher in patients living with frailty at 7 days (2.6% vs 0.2%), 30 days (7.9% vs 0.9%) and 90 days (15.5% vs 2.4%). Adjusted ORs for mortality for those with frailty compared with more robust patients were 9.9 (95% CI 2.1 to 46.5) for 7-day, 6.0 (95% CI 3.0 to 12.2) for 30-day and 5.7 (95% CI 3.6 to 9.1) 90-day mortality. Patients living with frailty had higher admission rates, 58% versus 36%, a difference of 22% (95% CI 17% to 26%), longer ED LOS, 5 hours:08 min versus 4 hours:36 min, a difference of 31 min (95% CI 14 to 50), and longer in-hospital LOS, 4.8 days versus 2.7 days, a difference of 2.2 days (95% CI 1.2 to 3.0).Conclusion Patients living with frailty, had significantly higher mortality and admission rates as well as longer ED and in-hospital LOS compared with robust patients. The results confirm the capability of the CFS to risk stratify short-term mortality in older ED patients.Trial registration number NCT04877028.

Place, publisher, year, edition, pages
BMJ PUBLISHING GROUP , 2024. Vol. 41, no 9, p. 514-519
Keywords [en]
frailty; emergency department; triage; geriatrics; clinical assessment
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
URN: urn:nbn:se:liu:diva-206308DOI: 10.1136/emermed-2023-213444ISI: 001278779500001PubMedID: 39053972OAI: oai:DiVA.org:liu-206308DiVA, id: diva2:1889390
Note

Funding Agencies|Region Ostergotland [RO-965951]

Available from: 2024-08-15 Created: 2024-08-15 Last updated: 2025-04-28Bibliographically approved
In thesis
1. Assessing Frailty in the Emergency Department: Feasibility and Performance of the Clinical Frailty Scale in a Swedish context
Open this publication in new window or tab >>Assessing Frailty in the Emergency Department: Feasibility and Performance of the Clinical Frailty Scale in a Swedish context
2025 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

With increasing age, the risk of frailty rises due to deterioration of several physiological systems, reducing the body’s reserve capacity. Recognising this vulnerability during care encounters is important both for understanding prognosis and recovery goals, and for planning care to reduce adverse outcomes.

Traditional emergency department (ED) risk stratification methods often fail to detect risks related to frailty, which is why interest in incorporating frailty assessment in EDs has grown. Several instruments have been developed, including the Clinical Frailty Scale (CFS). The CFS has been evaluated across many specialties and is recommended for use in the ED. However, no such research has been conducted in Swedish EDs, and studies under real clinical conditions remain limited.

Therefore, this thesis aims to examine whether the CFS is a useful tool for assessing frailty in older ED patients in Sweden. Specifically, we sought to evaluate its interrater reliability, prognostic accuracy, feasibility and the perspectives of patients.Study I was an observational study assessing IRR by collecting independent CFS assessments from the physician, registered nurse, and assistant nurse responsible for the patient. IRR was assessed in 100 patients, with 300 assessments conducted. IRR was moderate to good, with an ICC of 0.78 (95% CI 0.72–0.84).

Study II examined the prognostic value of the CFS by collecting staff-assessed CFS scores for 1840 older patients. The primary outcome was 30-day mortality, compared between patients with and without frailty. We found that 30-day mortality was significantly higher in patients with frailty compared to those considered robust (7.9% vs 0.9%). Frailty was independently associated with 30-day mortality, with an odds ratio of 6.0 (95% CI 3.0–12.2) after adjusting for confounding factors.

Study III employed a mixed methods design to examine the feasibility of the CFS in an ED setting. We collected data on 4235 ED visits and explored staff experiences through a questionnaire. The overall assessment completion rate was 47%, with more completed in older age groups. The most frequently reported barrier to assessment was high workload. Staff generally perceived the CFS to be relevant, although some questioned its benefits for patients in the ED.

Study IV had a qualitative design and included video-recorded CFS assessments and interviews with patients. A thematic analysis was conducted. Most older patients perceived frailty screening as positive or indifferent, though the experience could further benefit from a better understanding of the assessment’s purpose and consequences. Patients emphasised the importance of relationship-oriented communication, influencing their willingness to share information about their lives.

The CFS demonstrates moderate to good IRR and a strong association with mortality, supporting its usefulness in the ED. However, barriers such as high ED workload and mixed staff perceptions regarding its relevance to ED care impact routine use. Older patients generally respond positively to CFS while it is indicated that it can be further improved with clearer explanations of its purpose and potential consequences.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2025. p. 48
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1977
Keywords
Emergency department, Frailty, Geriatrics, Clinical Frailty Scale, Risk stratification
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-213266 (URN)10.3384/9789181180664 (DOI)9789181180657 (ISBN)9789181180664 (ISBN)
Public defence
2025-06-04, Berzeliussalen, Building 463, Campus US, Linköping, 13:00 (Swedish)
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Available from: 2025-04-28 Created: 2025-04-28 Last updated: 2025-04-28Bibliographically approved

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Munir Ehrlington, SamiaHörlin, ErikaToll, RaniWretborn, JensBjörk Wilhelms, Daniel

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Munir Ehrlington, SamiaHörlin, ErikaToll, RaniWretborn, JensBjörk Wilhelms, Daniel
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