liu.seSearch for publications in DiVA
EnglishSvenskaNorsk
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Belimumab concentration measurements using a homologous anti-idiotype immunoassay
Sanquin Diagnost Serv, Netherlands.
Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Orebro Univ, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Medicine Center, Department of Rheumatology.ORCID iD: 0000-0003-4590-4866
Lund Univ, Sweden.
Show others and affiliations
2024 (English)In: JIM - Journal of Immunological Methods, ISSN 0022-1759, E-ISSN 1872-7905, Vol. 532, article id 113717Article in journal (Refereed) Published
Abstract [en]

Monitoring belimumab concentrations in patients can be a valuable tool for assessing treatment response and for personalizing drug doses. Various assay formats may be used to measure concentrations of therapeutic monoclonal antibodies. A particularly useful format involves the use of anti-idiotype monoclonal antibodies, selected to be highly specific to the antibody of interest. Here, we describe the development of a specific, high-affinity anti-idiotype antibody to belimumab, and the application of this antibody in a homologous sandwich ELISA to measure belimumab concentrations.
Place, publisher, year, edition, pages
ELSEVIER , 2024. Vol. 532, article id 113717
Keywords [en]
PK/ADA assays; Anti-idiotype antibodies; Rabbit monoclonal antibodies; Belimumab
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:liu:diva-206389DOI: 10.1016/j.jim.2024.113717ISI: 001272244200001PubMedID: 38960066OAI: oai:DiVA.org:liu-206389DiVA, id: diva2:1889884
Note

Funding Agencies|Swedish Rheumatism Association [R-969696]; King Gustaf V's 80-year Foundation [FAI-2020-0741]; Swedish Society of Medicine [SLS-974449]; Nyckelfonden [OLL-974804]; Professor Nanna Svartz Foundation [2021-00436]; Ulla and Roland Gustafsson Foundation; Region Stockholm [FoUI-955483]; Karolinska Institutet

Available from: 2024-08-16 Created: 2024-08-16 Last updated: 2024-10-23

Open Access in DiVA

fulltext(337 kB)42 downloads
File information
File name FULLTEXT01.pdfFile size 337 kBChecksum SHA-512
bec9478abe986aabaf41a6493351840af299c226f92c29d9447b11bb524a1f39399a3eb744aeee210c61a0380e06f7e52fdcfeee06dba7d3a6f224db84eb2e81
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Walhelm, TomasSjöwall, Christopher
By organisation
Division of Inflammation and InfectionFaculty of Medicine and Health SciencesDepartment of Rheumatology
In the same journal
JIM - Journal of Immunological Methods
Biomedical Laboratory Science/Technology

Search outside of DiVA

GoogleGoogle Scholar
Total: 42 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 41 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
v. 2.47.0
|
Accessibility
|
DiVA portal
|
DiVA Log in
|
Contact us
|
LiU University Library
|
SwePub
|
Uppsök