Detection of scattering and absorption properties in both visible and near-infrared regions are crucial to quantify multiple functional responses in tissue. We developed a compact, clinical spatial frequency domain imaging (SFDI) system around a custom, nine wavelength, compound-eye camera, spanning ~450-1000nm. In addition to the characterization and validation of this device, we performed a preliminary in-vivo investigation to evaluate the imager’s ability to characterize dermal response under a noxious heating protocol. Increases in hemoglobin and water concentration are detected as well as slight alterations in the reduced scattering spectrum that maybe correlated with cellular and extra-cellular reactivity.