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Evaluation of the Biocompatibility of Poly(benzimidazobenzophenanthroline)(BBL) Polymer Films with Living Cells
Ist Italiano Tecnol, Italy; Univ Napoli Federico II, Italy.
Univ Catania, Italy; CSGI, Italy.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
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2025 (English)In: Small, ISSN 1613-6810, E-ISSN 1613-6829, Vol. 21, no 5, article id 2404451Article in journal (Refereed) Published
Abstract [en]

The integration of organic electronic materials with biological systems to monitor, interface with, and regulate physiological processes is a key area in the field of bioelectronics. Central to this advancement is the development of cell-chip coupling, where materials engineering plays a critical role in enhancing biointerfacing capabilities. Conductive polymers have proven particularly useful in cell interfacing applications due to their favorable biophysical and chemical properties. However, n-type conductive polymers remain underexplored, primarily due to their limited long-term stability. In this study, it is demonstrated that the conductive polymer poly(benzimidazobenzophenanthroline) (BBL), commonly used in organic electronic devices, can effectively support neuronal cell viability and spreading, both as a bare cell culture material and when coated with exracellular matrix proteins. This work provides a preliminary validation of BBL's potential for future integration into bioelectronic devices and in biointerfacing.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2025. Vol. 21, no 5, article id 2404451
Keywords [en]
BBL; cell-chip coupling; in vitro biocompatibility; neuronal cells; organic bioelectronics
National Category
Materials Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-210671DOI: 10.1002/smll.202404451ISI: 001382045900001PubMedID: 39711257Scopus ID: 2-s2.0-85212797657OAI: oai:DiVA.org:liu-210671DiVA, id: diva2:1925602
Note

Funding Agencies|Projekt DEAL

Available from: 2025-01-09 Created: 2025-01-09 Last updated: 2025-09-18

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