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Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses
Univ Ottawa, Canada; Ottawa Hosp, Canada; Ottawa Hosp Res Inst OHRI, Canada; Kings Coll London, England; Univ Southampton, England; NHS Trust, England; Charite Univ Med Berlin, Germany.
Univ Greenwich, England.
Univ Southampton, England.
Kings Coll London, England; Univ Catolica, Uruguay.
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2025 (English)In: European Neuropsychopharmacology, ISSN 0924-977X, E-ISSN 1873-7862, Vol. 90Article in journal (Refereed) Published
Abstract [en]

There is no multi-country/multi-language study testing a-priori multivariable associations between non-modifiable/modifiable factors and validated wellbeing/multidimensional mental health outcomes before/during the COVID-19 pandemic. Moreover, studies during COVID-19 pandemic generally do not report on representative/weighted non-probability samples. The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is a multi-country/multi-language survey conducting multivariable/LASSO-regularized regression models and network analyses to identify modifiable/non-modifiable factors associated with wellbeing (WHO-5)/composite psychopathology (P-score) change. It enrolled general population-representative/weighted-non-probability samples (26/04/2020-19/06/2022). Participants included 121,066 adults (age=42 +/- 15.9 years, females=64 %, representative sample=29 %) WHO-5/P-score worsened (SMD=0.53/SMD=0.74), especially initially during the pandemic. We identified 15 modifiable/nine non-modifiable risk and 13 modifiable/three non-modifiable protective factors for WHO-5, 16 modifiable/11 non-modifiable risk and 10 modifiable/six non-modifiable protective factors for P-score. The 12 shared risk/protective factors with highest centrality (network-analysis) were, for non-modifiable factors, country income, ethnicity, age, gender, education, mental disorder history, COVID-19-related restrictions, urbanicity, physical disorder history, household room numbers and green space, and socioeconomic status. For modifiable factors, we identified medications, learning, internet, pet-ownership, working and religion as coping strategies, plus pre-pandemic levels of stress, fear, TV, social media or reading time, and COVID-19 information. In multivariable models, for WHO-5, additional non-modifiable factors with vertical bar B vertical bar>1 were income loss, COVID-19 deaths. For modifiable factors we identified pre-pandemic levels of social functioning, hobbies, frustration and loneliness, and social interactions as coping strategy. For P-scores, additional non-modifiable/modifiable factors were income loss, pre-pandemic infection fear, and social interactions as coping strategy. COH-FIT identified vulnerable sub-populations and actionable individual/environmental factors to protect well-being/mental health during crisis times. Results inform public health policies, and clinical practice.
Place, publisher, year, edition, pages
ELSEVIER , 2025. Vol. 90
Keywords [en]
Covid-19; COH-FIT; Survey; P-factor; Well-being; Psychiatry
National Category
Epidemiology
Identifiers
URN: urn:nbn:se:liu:diva-211210DOI: 10.1016/j.euroneuro.2024.07.010ISI: 001381402000001PubMedID: 39341043Scopus ID: 2-s2.0-85205003992OAI: oai:DiVA.org:liu-211210DiVA, id: diva2:1931911
Available from: 2025-01-28 Created: 2025-01-28 Last updated: 2025-03-14

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Dragioti, Elena

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