There are important differences in epidemiology, pathophysiology, heart failure (HF) type, prognosis, and treatment. Women with HF have a higher incidence of HF with preserved ejection fraction (HFpEF) but in general treatment recommendation for guideline directed therapy are similar for men and women. There are still gaps in the management of women with HF. Self-care behaviour is vital for optimal outcomes for patients with HF and although there is no difference in the content of self-care advice, the challenges for optimal self-care might be different for women. A person-centred approach to treat and support women with HF is needed to attain optimal outcomes.