This paper presents a discussion and analysis of recent developments and investigations into the multifaceted role of Fermi Problems as content, connectors, and integrators in mathematics and across the STEAM disciplines. In particular, the role of Fermi problems as interdisciplinary activities in the context of mathematical modelling and problem posing is discussed, as well as the utility of the framework known as the Fermi Problem Activity Template (FPAT) as a tool for supporting the design and implementation of Fermi problems at different levels. The paper then proceeds to present a number of illustrative examples and recommendations for facilitating the integration of Fermi problems into curriculum materials and classroom practice. Furthermore, it outlines potential avenues for future research in this field.