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Bioimpedance and Symptom Guided Fluid Management in Hemodialysis: A Multicenter Pre-Post Implementation Study
Uppsala Univ, Sweden.
Uppsala Univ, Sweden.
Uppsala Univ, Sweden.
Uppsala Univ, Sweden; Gävle Cent Hosp, Sweden.
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2026 (English)In: Hemodialysis International, ISSN 1492-7535, E-ISSN 1542-4758Article in journal (Refereed) Epub ahead of print
Abstract [en]

Background Optimizing volume status is central to hemodialysis care and may influence patient-reported outcome measures as recovery time. We evaluated the implementation of a structured decision aid (Recova) integrating symptom assessment with bioimpedance spectroscopy in routine hemodialysis practice.Methods A prospective multicenter pre-post within-subjects study was conducted in 10 Swedish hemodialysis clinics. Clinics adopted the intervention on a staggered schedule based on local readiness. Participants were assessed at baseline and after 12 weeks. Outcomes included bioimpedance spectroscopy-derived overhydration and extracellular water, patient-reported recovery time (hours to resume usual activities), and a fluid-related symptom score. Paired measurements were compared.Results Of 404 screened patients, 129 consented and 123 initiated the intervention. Recovery time data were available at both time points for 110 participants. Overhydration decreased from 2.6 +/- 1.7 to 2.3 +/- 2.0 L (p = 0.04) and extracellular water from 18.4 +/- 4.0 to 18.0 +/- 3.8 L (p = 0.01). Mean recovery time did not change significantly (6.7 +/- 7.1 to 5.8 +/- 6.2 h; p = 0.22) and median recovery time remained 4 h (IQR 1-10). Fluid-related symptom burden declined over the intervention period. No harms were reported; 13 participants did not complete the 12-week intervention.Conclusions In this multicenter pre-post evaluation, implementation of Recova was associated with modest improvements in bioimpedance spectroscopy-derived volume metrics and fluid-related symptoms, while recovery time did not change significantly. Controlled studies are needed to determine effectiveness and to identify which patients may benefit.

Place, publisher, year, edition, pages
WILEY , 2026.
Keywords [en]
bioimpedance spectroscopy; clinical decision support; fluid management; hemodialysis; patient-reported outcomes; recovery time
National Category
Nursing
Identifiers
URN: urn:nbn:se:liu:diva-226694DOI: 10.1111/hdi.70109ISI: 001811244600001PubMedID: 42402974Scopus ID: 2-s2.0-105043857434OAI: oai:DiVA.org:liu-226694DiVA, id: diva2:2093439
Note

Funding Agencies|Regionala Forskningsrdet Uppsala/rebro [RFR-981084]; Sweden and Stiftelsen fr Njursjuka (the Foundation for Kidney Patients), Sweden; Stiftelsen fr Njursjukas frening i CUWX-lnens forskningsfond - a regional kidney patients' association representing Uppsala and Vstmanland counties within Njurfrbundet (the Swedish Kidney Foundation); Uppsala Universitet

Available from: 2026-08-19 Created: 2026-08-19 Last updated: 2026-08-19

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Indurain, Ainhoa
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Division of Diagnostics and Specialist MedicineFaculty of Medicine and Health SciencesDepartment of Nephrology
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